Long-term use of oxycodone for chronic pain can lead to several side effects and risks. Physically, it may cause constipation, nausea, dizziness, and hormonal imbalances, including reduced testosterone levels. Dependence and addiction are significant risks, even when taken as prescribed. Mental health effects such as depression, anxiety, and mood swings may also occur. Prolonged use can impair cognitive function and memory. There’s also a risk of respiratory depression, especially at higher doses. If stopped suddenly, withdrawal symptoms like muscle aches, sweating, and irritability may occur. It’s important to use oxycodone under close medical supervision, especially for long-term treatment, to monitor for side effects and explore safer alternatives if needed.