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The objective of this study was to systematically review the impact of physical activity on quality of life in the elderly population. Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Bireme, Scopus, Sportdiscus, SPORTdiscus and PEDro were searched for articles published through April 2008. English, French, German and Dutch language studies were included. Psychometric instruments measuring quality of life were analyzed using standardised effect sizes (ES) for quantitative variables and qualitative variables (standardised difference in means). Twenty-eight studies were eligible, 17 using quality of life as an outcome. Main findings were: positive effects of physical activity on cognitive function (10 studies), anxiety (four studies), depression (one study), pain (one study) and balance (one study) and negative effects on general health (three studies). Quality of life showed no effects of physical activity. The most common method used to measure quality of life was the SF-36; the majority used analyses comparing groups. Physical activity is beneficial for certain subgroups of the elderly population. However, the quality of life of these groups does not seem to benefit from physical activity. The evidence for benefit of physical activity on quality of life is still weak.Purification and partial characterization of a Fc-binding protein from a human monocyte-like cell line.
We have isolated a factor that binds to IgG Fc from the high-molecular-weight IgG fraction of human serum. The Fc-binding factor was purified from a human monocyte-like cell line, TF-1, using chromatography on IgG-Sepharose. A major protein was observed at the same position on the gel as IgG on which IgG Fc