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In 2004, Gary Smith at the University of Pittsburgh and his colleagues published work on a new technique, the Thermal Micro Electrical Stimulation (TMES) devices, to stimulate the brain directly (12). Using an apparatus that preserves the temperature at which the tissue is stimulated, the researchers found that electrical stimulation of the motor cortex results in muscle activity in the ipsilateral elbow and shoulder muscles in paralyzed patients. Their study gave rise to a new line of research in humans, with the development of a new technique to restore motor function and the possible mental restoration of the brain in paralyzed patients (66).
On the homecoming of the Starship Enterprise in 1979 Earth learned that the planet Quraqua had become home to humans by migrating alpha particles. A few months later, the news was shattered: The Quratan biologists had found a way to kill off 99.99% of its human inhabitants through habitat destruction. In search of explanations, the Enterprise traveled to Quraqua, where the Quratan leader answered with a simple plea: Humans must be taught to live in harmony with their environment.
Techniques also have been devised to attempt to assess the degree of injury and the effects of treatment. Initial assessments focus on patients with blunt head trauma, reporting motor deficits (9, 10). Acquired brain injury may also be assessed quantitatively using computed tomography or MRI, although radiologists are not specialists in this field and their interpretation proves to be a problematic issue (57). The best assessment, however, is by pharmacokinetic biomarkers, which can be used to predict post-injury outcome and drug toxicity in toxicity studies (71).
Despite many advances in the diagnosis and treatment of critical illness, progress remains slow. Comorbidity among patients, delayed care, and lack of evidence-based medicine all represent significant hurdles to optimal provision of care for critical illness. Furthermore, audit will help to ensure the focus is adequately directed towards measures that can have a lasting effect. The scope, structure, and processes of audit could be improved at multiple levels, including patient safety and clinical effectiveness, patient care pathways, and health service delivery.
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