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The pathogenesis of amyotrophic lateral sclerosis (ALS) is poorly understood and toxic free radical theories of the disease are controversial. Therefore, the pathophysiology of ALS, in particular, the metabolic defects that lead to loss of central nervous system function, need to be investigated. Glutamatergic neurotransmission is affected in ALS, and we have found abnormalities in the glutamatergic system, such as glutamate, glutamine, and gamma-aminobutyric acid, in the corticostriatal pathway of a transgenic mouse model of ALS. In this report, we show that glutamate is increased and glutamate transporter function is decreased in the striatum of transgenic mice. These results indicate that the metabolism of glutamate is abnormal in the striatum in ALS.Tag: Rare Diseases
Hope, Empathy, and Action to Advance the Cure for Bethune-Illustrated book The Rare Disease Library is the only book of its kind, exploring the rare diseases diagnosed by Up to 20% of Americans and including new information about…
The 5,000 Genomes Project is an NIH National Institute of Allergy and Infectious Diseases initiative to determine the complete genome sequences of 5,000 individuals from four major populations (Americans of European, African and East Asian ancestry…
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is a National Human Genome Research Institute (NHGRI) initiative to determine the complete genome sequences of 1,000 individuals from each of the five major world populations (Africans, East Asians, South Asians, Europeans,…
Hope, Empathy, and Action to Advance the Cure for Bethune-
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