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Genetic predisposition of sarcoidosis has been proposed based on familial aggregation and clinicopathologic findings. However, genetic data on sarcoidosis are scarce. It has been reported that 2 polymorphisms of the angiotensin-converting enzyme (ACE) gene are associated with ACE activity, and are associated with some autoimmune diseases. We therefore conducted a study to test the hypothesis that polymorphisms of the ACE gene are involved in the susceptibility for sarcoidosis. Using restriction fragment length polymorphism, we studied the presence of 5 polymorphisms, I/D(+301), M/I(-460), VNTR(+954), I/D(+163), and G/A(+121), in 21 patients with sarcoidosis and 88 healthy controls. The frequency of ACE genotype I/D (+301) did not differ between patients and controls, but the genotype I/I and the genotype II/II were more common in patients than in controls. In addition, I/I genotype was significantly associated with higher erythrocyte ACE activity in patients but not in controls. The results suggest that polymorphisms of the ACE gene are not a major determinant of susceptibility for sarcoidosis.Q:
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