Single domain antibodies represent the smallest antibody that has been proven to have diagnostic and therapeutic usefulness. They are antibody fragments that are engineered from single monomeric variable domains of either camelids’ heavy-chain antibody (VHH) or cartilaginous fishes’ IgNAR (VNAR). On the other hand, it is also possible to develop single domain antibodies from camelized human antibodies.
Learn more: camel antibody structure
